Capillary Perfusion and Wall Shear Stress Are Restored in the Coronary Circulation of Hypertrophic Right Ventricle

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Capillary perfusion and wall shear stress are restored in the coronary circulation of hypertrophic right ventricle.

It has been shown that right ventricle (RV) hypertrophy involves significant compensatory vascular growth and remodeling. The objective of the present study was to determine the functional implications of the vascular growth and remodeling through a full flow analysis of arterial tree down to first capillary segments. A computer reconstruction of RV branches including the proximal right coronar...

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The role of wall shear stress in the assessment of right ventricle hydraulic workload.

Pulmonary hypertension (PH) is a devastating disease affecting approximately 15-50 people per million, with a higher incidence in women. PH mortality is mostly attributed to right ventricle (RV) failure, which results from RV hypotrophy due to an overburdened hydraulic workload. The objective of this study is to correlate wall shear stress (WSS) with hemodynamic metrics that are generally accep...

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Comparison of the Graft Angles Effects on the Temporal Wall Shear Stress Gradients in the Aorto-Coronary and Coronary-Coronary Bypasses

In this theoretical study, the effect of various types of bypass graft angles on the flow field, has been investigated specially on the temporal Wall Shear Stress (WSS) on the toe, heel and some locations on the bed of the Left Anterior Descending (LAD) artery at the anastomoses areas in the Aorto-Coronary (AC) and Coronary-Coronary (CC) bypasses. Flow fields in both bypasses with angles of...

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Correlation of Wall Shear Stress and Intimal Thickening in the Right Coronary Artery

INTRODUCTION Atherosclerosis is a common arterial disorder, and is of particular clinical significance when it occurs in the coronary arteries since it can result in ischemic heart disease and/or myocardial infarction. The development of atherosclerotic lesions is linked to systemic risk factors including hypertension, hypercholesterolemia, heredity, and smoking [1] as well as local biomechanic...

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Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery.

OBJECTIVE Low wall shear stress has been implicated in atherogenesis throughout the arterial tree, including the right coronary artery (RCA). The objective of this study was to determine the level of covariation of intimal thickness and wall shear stress in the human RCA. METHODS AND RESULTS Postmortem histological measurements of intimal thickness were compared with wall shear stresses calcu...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2007

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.0000257777.83431.13